<p>This entry represents PQQ-dependent dehydrogenases from the methanol/ethanol family, which has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulphide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see <db_xref db="INTERPRO" dbkey="IPR002372"/>). Characterised members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of <taxon tax_id="442">Gluconobacter oxydans</taxon> (Gluconobacter suboxydans), a homodimeric ethanol dehydrogenase in <taxon tax_id="287">Pseudomonas aeruginosa</taxon>, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in <taxon tax_id="408">Methylobacterium extorquens</taxon>.</p> PQQ-dependent dehydrogenase, methanol/ethanol family